I'm mainly into my gaming podcasts so my list consists of the following:
A life well wasted (US based, stories in and around gaming, focuses on the people more than the games)
Adam and Joe (BBC, old favorites from my younger years)
Custom PC Podcasts (PC Tech news .. might be defunct not had a new one out in a while)
Digital Cowboys Video Games (UK based games chat)
Dungeons & Dragons Podcast (Nerd alert
Will Wheaton and the Penny Arcade boys play D&D with Wizards of the Coast)
Friday Night Comedy from the BBC (Radio 4)
Gamehounds Podcast (US based gaming chat)
Gamers with jobs (US based games chat, from gamers who have mainly none game related jobs.. i.e. same free time as myself)
Giant Bombcast (Games news from some ex Gamespot guys)
Material World (BBC Science program)
Rebel FM (Ex 1-Upers games chat)
Stephen Fry's PODGRAMS (Infrequent, but quality)
Gamespot UK Podcast (Yet more games news)
The Geekbox (Games chat, tv show chat, geek chat from some more ex 1-upers)
Links can be provided on request.. maybe we need a nice export function??